Biological DNA Sensor: Chapter 12. Adjuvants Targeting the DNA Sensing Pathways - Alum Based Adjuvants Book PDF, ePub eBook

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Book Descriptions:
Aluminum-based adjuvants (alum) are among the oldest and most widely used vaccine adjuvants. After decades of largely empirical use, the last years have witnessed a flurry of studies aiming to decipher the immunological mechanisms of action of alum. Along with other hypotheses, recent reports support that alum induces the release by host cells of their own DNA at sites of injection. Extracellular self-DNA would in turn activate the innate immune system through known and yet to be identified innate immune pathways and in this way boost the adaptive response to vaccine antigens. This chapter discusses the evidence supporting the view of self-DNA as a damage-associated molecular pattern implicated in the adjuvant activity of alum, its possible links with other proposed mechanisms, as well as future directions in the area of the sensing of self-nucleic acids in the modulation of immunological responses to vaccines.

Biological DNA Sensor: Chapter 12. Adjuvants Targeting the DNA Sensing Pathways - Alum Based Adjuvants by Christophe J. Desmet

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