Chapter 018, The Rabbit as an Experimental Model (American College of Laboratory Animal Medicine) Book PDF, ePub eBook

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Book Descriptions:

NOTE: This is a single chapter excerpted from the book The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, made available for individual purchase. Additional chapters, as well as the entire book, may be purchased separately.

This chapter demonstrates the continued high use of rabbits in the areas of atherosclerosis, ophthalmic disease, infectious disease, orthopedic research, and experimental neoplastic research. The chapter provides an overview of these conditions. The total number of rabbits used for research and testing in the United States has declined from a peak value of approximately 550,000 per year in the late 1980s to the current level of approximately 230,000. Several factors contribute to this decline and the most important being the rapid expansion of genetically engineered rodent models, which largely replace rabbits for investigation of many diseases such as candidiasis and variola. Even for conditions such as herpes simplex keratitis in which rabbits are still a classic and frequently used model, murine models have been developed to replace rabbits. These tests were developed in the 1960s and adopted by the Environmental Protection Agency to meet the testing requirements of the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. The albino rabbit remains the preferred species for both of these tests.

Chapter 018, The Rabbit as an Experimental Model (American College of Laboratory Animal Medicine) by Mark Suckow

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